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Borderlands 4

Best Vex (Siren) Build and Leveling Guide

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Borderlands 4 - Vex Best Build

This is a build guide for Vex the Siren effectively utilizing the Phase Phamiliar summon in Borderlands 4. See the best build, skills, guns, and gear to use for Vex, along with a leveling guide and character playstyle here!

All Vex Guides
Leveling Build Vex Cosmetics
Boss Farm Build Bleed Build
Vex Skill Trees and Voice Actor

Best Vex (Siren) Build

Jump to a Section!
Skill Tree Skill Progression Weapons
Class Mod Enhancements

Vex Best Skill Tree and Action Skill

Skill Tree Phase FamiliarHere Comes Trouble
Action Skill: Phase Phamiliar

The Here Comes Trouble tree with the Phase Phamiliar action skill is our pick for the best Siren build. This skill tree focuses on survivability through healing and overshields with Kill Skills while steadily ramping up your damage with guns, ordnances, and your loyal summon, Trouble.

With your Minion, you can tear through enemy hordes using Trouble alongside your guns and ordnance. Trouble also draws plenty of enemy aggro, giving you more room to survive and control the battlefield.

Vex Best Skills

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Skill Tree Skill Progression
Passives Capstone

Best Passive Skills

Here Comes Trouble
Vexcalation
Skill Tree Priority Skills
Phase FamiliarHere Comes Trouble
Grave Sustenance Icon Grave Command Icon Yowl and Bay Icon Vorpal Fiends Icon Shocking Attunement Icon Infusion Icon
Skill Tree Priority Skills
Incarnate IconVexcalation
Guns and Needles Icon Grave Sights Icon Fiendish Invigoration Icon Channeling Icon Target Prescience Icon

Best Passive Skills

Recommended Skill Progression
Grave Sustenance Icon Lvl 2 Grave Sustenance Icon Lvl 3 Grave Sustenance Icon Lvl 4 Grave Sustenance Icon Lvl 5
Grave Sustenance Icon Lvl 6 Yowl and Bay Icon Lvl 7 Grave Command Icon Lvl 8 Yowl and Bay Icon Lvl 9
Yowl and Bay Icon Lvl 10 Yowl and Bay Icon Lvl 11 Yowl and Bay Icon Lvl 12 Grave Command Icon Lvl 13
Vorpal Fiends Icon Lvl 14 Grave Command Icon Lvl 15 Vorpal Fiends Icon Lvl 16 Shocking Attunement Icon Lvl 17
Shocking Attunement Icon Lvl 18 Shocking Attunement Icon Lvl 19 Shocking Attunement Icon Lvl 20 Shocking Attunement Icon Lvl 21
Guns and Needles Icon Lvl 22 Guns and Needles Icon Lvl 23 Infusion Icon Lvl 24 Infusion Icon Lvl 25
Infusion Icon Lvl 26 Infusion Icon Lvl 27 Infusion Icon Lvl 28 Guns and Needles Icon Lvl 29
Grave Sights Icon Lvl 30 Grave Sights Icon Lvl 31 Fiendish Invigoration Icon Lvl 32 Fiendish Invigoration Icon Lvl 33
Fiendish Invigoration Icon Lvl 34 Fiendish Invigoration Icon Lvl 35 Fiendish Invigoration Icon Lvl 36 Target Prescience Icon Lvl 37
Target Prescience Icon Lvl 38 Target Prescience Icon Lvl 39 Target Prescience Icon Lvl 40 Target Prescience Icon Lvl 41
Vorpal Fiends Icon Lvl 42 Vorpal Fiends Icon Lvl 43 Vorpal Fiends Icon Lvl 44 Channeling Icon Lvl 45
Channeling Icon Lvl 46 Channeling Icon Lvl 47 Channeling Icon Lvl 48 Channeling Icon Lvl 49
Grave Sights Icon Lvl 50

From levels 2–16, focus on the passives in the Here Comes Trouble tree that buff your Summon, survivability, Kill Skill bonuses, and raw damage. These make Trouble incredibly powerful, especially during its Badass form.

At level 17, take the Hexus Nexus Augment, then start investing in Shocking Attunement, to rush unlocking your Unsealed Capstone.

As you approach the level cap, continue leveling passives and Kill Skills that enhance Repkits. Pick up Guns and Needles, and Fiendish Invigoration in the Vexcalation tree for more Repkit skills that synergize extremely well with Infusion.

Vex Best Augment

Lvl 6 Lvl 16
Blink Strike Icon Blink Strike Hexus Nexus Icon Hexus Nexus

In the early game, use Blink Strike to finish off enemies below 50% HP. Later, swap it for Hexus Nexus, to draw aggro, allowing you to shoot at enemies freely.

Hexus Nexus effectively turns Trouble into a much stronger tank and crowd-control tool. Thanks to the max health, healing, and overshield passive skills invested, Trouble will stay healthy through most fights despite taking much of the aggro.

Vex Best Capstone

Unsealed Icon Unsealed
Tree Here Comes Trouble
(Branch 3)
Effect
Trouble will now Mark his current target, causing them to take increased Gun Damage from Vex. Kill Skill. When a Marked enemy is killed, Trouble gains a Stack of Unsealed for a Duration, granting Health Regeneration and increased Damage. While Phase Phamiliar is active, Unsealed effects are doubled. This effect can stack.

Unsealed allows Trouble to mark enemies and receive +50% Gun Damage from Vex, making it an exceptional skill especially against Bosses and Badasses.

Command Trouble to attack enemies, then use a Repkit to stack multiple buffs, allowing you to blitz through even the tankiest enemies!

Vex Best Weapons

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Best Manufacturer Best Weapon Type

Best Weapon Type for Vex: SMGs

SMGs are Vex’s best weapon choice. They complement her fast-paced playstyle as well, sticking close to Trouble and wreaking havoc up close.

Best Manufacturer for Vex: Maliwan

Maliwan weapons and licensed parts pair great with Vex, allowing Vex to make full use of Infusion, and receiving additional stats when using Shock Weapons from your Skills.

Vex Best Class Mod

Teen Witch

Class Mod Effects
Teen Witch Recommended Skills:
Yowl and Bay Icon Vorpal Fiends Icon Infusion Icon
Legendary Bonus
When Vex has Maximum Health, her Lifesteal partially applies to Shields. When Vex has Maximum Shield, her Lifesteal partially grants Overshield.

Vex Best Enhancement Mods

Maliwan Enhancements

Enhancement Effects
Maliwan Enhancement Synthesizer - Guns with Maliwan-licensed parts have +25% Status Effect Damage
Transfuser - On kill, Guns with Maliwan-licensed parts spread their active Status Effect to up to 3 nearby targets.

Equipping a Maliwan Enhancement with either Synthesizer or Transfuser synergize well with this build since it gives Vex and Trouble additional Status Effect Damage.

Transfuser is a

Vex (Siren) Leveling Guide

Use Action Skill as Often as Possible

Using Here Comes Trouble as often as possible allows you to capitalize on Trouble's Badass Form, which should be enough to take on most normal enemies.

This allows you to run around the battlefield and use your guns to focus on other enemies, making clearing areas faster and more efficient.

Look For Order Repkits

As you approach the later stages of the build, start looking for Repkits with Order Licensed Parts, since these give you 2 Charges of your Repkit.

This improves Vex' survivability, while also giving you two charges to proc your buffs from Infusion.

Complete Side Missions and Bounties

To farm EXP efficiently, accept Side Missions and Bounties whenever possible, instead of just aimlessly wandering the map.

Side Missions and Bounties reward you with EXP upon completion, and most of these require you to fight various enemies, allowing you to gain EXP from multiple sources per mission.

How to Level Up Fast

Best Vex (Siren) Build Overview

Here Comes Trouble Summon Build

Skills
Phase Phamiliar
Phase Phamiliar
Guns and Needles Icon Grave Sights Icon Grave Sustenance Icon Fiendish Invigoration Icon Grave Command Icon Yowl and Bay Icon Channeling Icon Target Prescience Icon Vorpal Fiends Icon Shocking Attunement Icon Infusion Icon
Best Weapon Type Best Manufacturer
SMG Maliwan

This build centers on the Phase Phamiliar action skill, along with passives that boost survivability and damage. Equip SMGs with Vex to focuse on fast-paced close-range combat, and take advantage of Maliwan weapons and accessories for their powerful elemental effects.

Best Vex (Siren) Build Playstyle

Summon-Focused Damage Playstyle

With the Here Comes Trouble skill tree, your Phase Phamiliar summon Trouble serves as a key source of both damage and utility. Throughout the story, Trouble remains a dependable ally, helping you level quickly and cut down enemies regardless of your loot quality.

Borderlands 4 Related Guides

Borderlands 4 - Builds

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Character Build
Vex the Siren IconVex
Phase Familiar IconBest Leveling Build
Rafa the Exo-Soldier IconRafa
Amon the Forgeknight IconAmon
Harlowe the Gravitar IconHarlowe

Comment

1 SkullReaper3297 days

How come this build uses only SMG's and not AR's (Assault Rifles), or a mixture of the 2?? I love using a mixture of all the guns except the shotguns. I know shotguns are for up close

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