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Borderlands 4

Bio-Bulkhead Drops and Location

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Bio-Bulkhead is a boss located in the Synthetic Nave in Borderlands 4. See Bio-Bulkhead's drop rewards, location, and tips on how to beat Bio-Bulkhead in this guide.

Bio-Bulkhead Drops

Bio-Bulkhead Drop Rewards
Sho Kunai Sho Kunai (Legendary Grenade)
Waterfall Waterfall (Legendary Grenade)

Bio-Bulkhead Location

Found in Synthetic Nave

Bio-Bulkhead is located in the Synthetic Nave, Dissected Plateau in Fadefields. Bio-Bulkhead appears as a boss encounter in the main mission, One Fell Swoop.

Bio-Bulkhead can also be repeatedly farmed after you complete One Fell Swoop. Return to the location after the main mission and spend cash at the Moxxi's Big Encore Machine near the entrance of the boss arena to re-farm it.

Borderlands 4 Interactive Map

How to Beat Bio-Bulkhead

How to Beat Bio-Bulkhead


Throw Locust Sample When Immune

Throw Locust Sample When Immune

At the beginning of the fight, and at the start of each health segment, Bio-Bulkhead becomes immune to all incoming damage. During this phase, grab a Locust Sample from the arena and throw it at the boss. This will temporarily disable its immunity and leave it vulnerable to your weapons.

Use Corrosive or Cryo Weapons

Use Corrosive Weapons

Once Bio-Bulkhead’s armor is exposed, Corrosive or Cryo weapons are the most effective choice, dealing bonus damage to its armor health bar. Shock, Radiation and Incendiary weapons are much less effective. If you run out of Corrosive options, Kinetic weapons can be used as backups.

Jump Over AOE Attacks

Jump Over AOE Attacks

Bio-Bulkhead frequently slams the ground, sending out a damaging AOE shockwave. Keep moving and time your jumps carefully to avoid taking damage.

Bio-Bulkhead Overview

Bio-Bulkhead
Mission One Fell Swoop
Point of Interest Synthetic Nave
Area Dissected Plateau
Region Fadefields
Weakness Corrosive

Borderlands 4 Related Guides

Borderlands 4 List of All Bosses Partial

List of Bosses

List of Bosses

Warden Scathe Splashzone Horace
The Oppressor Bio-Bulkhead Idolator Sol
Primordial Guardian Inceptus Sludgemaw Callous Harbringer of Annihilating Death
Callis, the Ripper Queen Genone Sidney Pointylegs
Bramblesong - -

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